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mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic.

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Chen Peixian[1] * ; Shi Xiaoye[1] * ; He Weixin[2] ; Zhong Guowei[3] ; Tang Yan[1] ; Wang Hailin[4,*2] ; Zhang Peidong[5,*1] ;
机构： [1]Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People‘s Republic of China [2]Nanfang Hospital, Southern Medical University/The First School of Clinical Medicine, Southern Medical University, No, Guangzhou, Guangdong, People‘s Republic of China [3]School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, People‘s Republic of China [4]Department of Cardiology, Heart Center, People‘s Hospital of Guangning County, Zhaoqing City, Guangdong, People‘s Republic of China [5]Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People‘s Republic of China
出处：
DOI： 10.1080/21645515.2022.2040330
ISSN：

关键词： COVID-19 mRNA vaccines infectious diseases immune responses clinical trial SARS-CoV-2

摘要：
As an acute respiratory infectious disease, COVID-19 threatens the safety of global public health. Given the current lack of specific treatment against this disease, research and development of vaccines have become sharp weapons for overcoming the pandemic. mRNA vaccines have become the lead in COVID-19 vaccination strategies due to their advantages, such as rapid industrial production and efficacy. A total of 137 COVID-19 vaccines have entered the clinical trial stage, among which 23 are mRNA vaccines, accounting for 17% of the total vaccines. Herein, we summarize the research and developmental processes of mRNA vaccines as well as the approach for protecting the human body against infection. Focusing on the latest clinical trial data of two COVID-19 mRNA vaccines from Pfizer and Modena, we discuss their effectiveness and safety. Finally, we analyze the challenges and problems that mRNA vaccines face in controlling the COVID-19 pandemic.

基金：
This research was funded by Guangdong Medical Science and Technology Research Foundation [A2020162, B2021182]; Guangdong Basic and Applied Basic Research Foundation [2020A1515010288]; Higher Education Teaching Reform Project of Southern Medical University [JG2019126, 2018JG43, JG2019130, JG201984]; Social welfare and basic research project of Zhongshan City, Guangdong Province [2021B1090].
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 3 区 医学
小类 | 3 区 生物工程与应用微生物 3 区 免疫学
最新[2025]版：
大类 | 3 区 医学
小类 | 3 区 生物工程与应用微生物 3 区 免疫学
JCR分区：
出版当年[2020]版：
Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q3 IMMUNOLOGY
最新[2023]版：
Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q2 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Zhujiang Hospital, Southern Medical University/The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, People‘s Republic of China
共同第一作者：
通讯作者：
通讯机构： [4]Department of Cardiology, Heart Center, People‘s Hospital of Guangning County, Zhaoqing City, Guangdong, People‘s Republic of China [5]Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People‘s Republic of China [*1]Department of Cardiology, Heart Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People‘s Republic of China [*2]Department of Cardiology, Heart Center, People’s Hospital of Guangning County, No.18, Renmin Road, Nanjie Town, Guangning County, Zhaoqing City, 526300, Guangdong, People’s Republic of China
推荐引用方式(GB/T 7714)：
Chen Peixian,Shi Xiaoye,He Weixin,et al.mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic.[J].HUMAN VACCINES & IMMUNOTHERAPEUTICS.2022,18(1):doi:10.1080/21645515.2022.2040330.
APA：
Chen Peixian,Shi Xiaoye,He Weixin,Zhong Guowei,Tang Yan...&Zhang Peidong.(2022).mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic..HUMAN VACCINES & IMMUNOTHERAPEUTICS,18,(1)
MLA：
Chen Peixian,et al."mRNA vaccine-a desirable therapeutic strategy for surmounting COVID-19 pandemic.".HUMAN VACCINES & IMMUNOTHERAPEUTICS 18..1(2022)

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