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Mapping the regulatory effects of herbal organic compounds on gut bacteria

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资源类型：
Pubmed体系：
作者：
Zhang Yulong[1,5] * ; Chen Ting[1,5] * ; Hao Xiaoqing[1,8,10] * ; Hu Yuanjia[2,11] ; Chen Manyun[1,5] ; Zhang Daiyan[2] ; Cai Hong[2] ; Luo Jun[3] ; Kong Lingyi[3] ; Huang Sutianzi[1,9] ; Huang Yuanfei[1,5,6,7] ; Yang Nian[1,9] ; Liu Rong[1,5,6,7] ; Li Qing[1,8,9] ; Yuan Chunsu[4] ; Wang Chongzhi[4] ; Zhou Honghao[1,5,6,7] ; Huang Weihua[1,5,6,7,*1] ; Zhang Wei[1,8,9,12,*1] ;
机构： [1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410078, P. R. China [2]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR 999078, P. R. China [3]Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China [4]Tang Center of Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL 60637, USA [5]Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China [6]Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, P. R. China [7]National Clinical Research Center for Geriatric Disorders, Changsha 410008, P. R. China [8]Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, P. R. China [9]The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, P. R. China [10]The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, P. R. China [11]DPM, Faculty of Health Sciences, University of Macau, Macao SAR 999078, P. R. China [12]Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha 410006, P. R. China
出处：
DOI： 10.1016/j.phrs.2023.106804
ISSN：

关键词： Herbal organic compounds Gut microbiota High-throughput screening Anticommensal activity Human microbiome

摘要：
Herbal organic compounds (HOCs) are bioactive natural products from medicinal plants and some traditional Chinese medicines (TCMs). Recently, ingestion of a few HOCs with low bioavailability has been associated with alterations in gut microbiota, but the extent of this phenomenon remains unclear. Here, we systematically screened 481 HOCs against 47 representative gut bacterial strains in vitro and found that almost one-third of the HOCs exhibited unique anticommensal activity. Quinones showed a potent anticommensal activity, while saturated fatty acids exhibited stronger inhibition of the Lactobacillus genus. Flavonoids, phenylpropanoids, terpenoids, triterpenoids, alkaloids and phenols displayed weaker anticommensal activity, but steroids, saccharides and glycosides had hardly any effect on strain growth. Notably, S-configuration HOCs demonstrated stronger anticommensal activity than R-configuration HOCs. The strict screening conditions ensured high accuracy (95%) through benchmarking validation. Additionally, the effects of HOCs on human fecal microbiota profiling were positively correlated with their anticommensal activity against bacterial strains. Molecular and chemical features such as AATS3i and XLogP3 were correlated with the anticommensal activity of the HOCs in the random forest classifier. Finally, we validated that curcumin, a polyhydric phenol with anticommensal activity, improved insulin resistance in HFD mice by modulating the composition and metabolic function of gut microbiota. Our results systematically mapped the profile of HOCs directly affecting human gut bacterial strains, offering a resource for future research on HOC-microbiota interaction, and broadening our understanding of natural product utilization through gut microbiota modulation.Copyright © 2023. Published by Elsevier Ltd.

基金：
This work was supported by the National Key Research and Development Program of China (No. 2021YFA1301200), the National Natural Scientific Foundation of China (Nos. 82073945, 81874329, 82074000 and 81472802), the Hunan Provincial Natural Science Foundation of China (2020JJ4878).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2025]版：
大类 | 2 区 医学
小类 | 1 区 药学
第一作者：
第一作者机构： [1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410078, P. R. China [5]Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410078, P. R. China [5]Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China [6]Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha 410078, P. R. China [7]National Clinical Research Center for Geriatric Disorders, Changsha 410008, P. R. China [8]Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, P. R. China [9]The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, P. R. China [12]Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha 410006, P. R. China [*1]Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410078, P. R. China
推荐引用方式(GB/T 7714)：
Zhang Yulong,Chen Ting,Hao Xiaoqing,et al.Mapping the regulatory effects of herbal organic compounds on gut bacteria[J].Pharmacological research.2023,193:106804.doi:10.1016/j.phrs.2023.106804.
APA：
Zhang Yulong,Chen Ting,Hao Xiaoqing,Hu Yuanjia,Chen Manyun...&Zhang Wei.(2023).Mapping the regulatory effects of herbal organic compounds on gut bacteria.Pharmacological research,193,
MLA：
Zhang Yulong,et al."Mapping the regulatory effects of herbal organic compounds on gut bacteria".Pharmacological research 193.(2023):106804

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