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Nanomaterials against intracellular bacterial infection: from drug delivery to intrinsic biofunction

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机构： [1]Department of Orthopedics, Academy of Orthopedics-Guangdong Province, Orthopedic Hospital of Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. [2]School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China. [3]Department of Applied Chemistry, Xi'an University of Technology, Xi'an, China. [4]Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. [5]State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, Macau SAR, China.

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关键词： intracellular infection drug delivery antibacterial reactive oxygen species bioactive nanomaterials

摘要：

Fighting intracellular bacteria with strong antibiotics evading remains a long-standing challenge. Responding to and regulating the infectious microenvironment is crucial for treating intracellular infections. Sophisticated nanomaterials with unique physicochemical properties exhibit great potential for precise drug delivery towards infection sites, along with modulating infectious microenvironment via their instinct bioactivity. In this review, we first identify the key characters and therapeutic targets of intracellular infection microenvironment. Next, we illustrate how the nanomaterials physicochemical properties, such as size, charge, shape and functionalization affect the interaction between nanomaterials, cells and bacteria. We also introduce the recent progress of nanomaterial-based targeted delivery and controlled release of antibiotics in intracellular infection microenvironment. Notably, we highlight the nanomaterials with unique intrinsic properties, such as metal toxicity and enzyme-like activity for the treatment of intracellular bacteria. Finally, we discuss the opportunities and challenges of bioactive nanomaterials in addressing intracellular infections.Copyright © 2023 Chen, He, Chen, He, Chen, Yang and Wang.

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出版当年[2022]版：

大类 | 2 区工程技术

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生物工程与应用微生物 4 区工程：生物医学

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第一作者机构： [1]Department of Orthopedics, Academy of Orthopedics-Guangdong Province, Orthopedic Hospital of Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China. [2]School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China.

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Nanomaterials against intracellular bacterial infection: from drug delivery to intrinsic biofunction

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