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Protective roles and mechanisms of Dendrobium officinal polysaccharides on secondary liver injury in acute colitis.

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机构: [1]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [2]Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, PR China [3]Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an 223002, Jiangsu, PR China [4]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [5]Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, College of Chemical Engineering, Huaiyin Institute of Technology,Huai’an 223003, Jiangsu, PR China [6]Guangdong Food and Drug Vocational College, Guangzhou 510520, Guangdong, PR China
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关键词: Dendrobium officinale polysaccharides Secondary liver injury in acute colitis Nrf-2 signaling pathway

摘要:
The purpose of this study was to investigate the protective roles and mechanisms of Dendrobium officinale polysaccharides (DOPS) on secondary liver injury in acute colitis. Firstly, the mice model of secondary liver injury in acute colitis was induced by 4% Dextran sodium sulfate (DSS). Inflammatory cell model was established by LPS-stimulated RAW264.7 cells. Then, the protective roles of DOPS were evaluated by both in vivo and in vitro experiment. The results showed that DOPS attenuated DSS-induced hepatic pathological damage, liver parameters, infiltration of macrophages, cytokines levels, MDA level and increased the antioxidant enzymes activities. In vitro, DOPS markedly inhibited inflammatory cytokines production and increased antioxidant enzymes activities. Finally, its molecular mechanisms were also observed. The results indicated that DOPS could down-regulated TNF-α signaling pathway and activated Nrf-2 signaling pathway in vivo and in vitro. These results suggested that DOPS may be an effective therapeutic reagent to attenuate secondary liver injury in acute colitis. Copyright © 2017 Elsevier B.V. All rights reserved.

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出版当年[2017]版:
大类 | 3 区 生物
小类 | 2 区 应用化学 2 区 高分子科学 3 区 生化与分子生物学
最新[2025]版:
大类 | 2 区 生物学
小类 | 2 区 生化与分子生物学 2 区 应用化学 2 区 高分子科学
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出版当年[2016]版:
Q1 POLYMER SCIENCE Q1 CHEMISTRY, APPLIED Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
最新[2023]版:
Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [4]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou 510006, Guangdong, PR China
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通讯机构: [1]Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [4]Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [*1]Guangzhou University of Chinese Medicine,Guangzhou 510006, Guangdong, PR China
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