个人中心| | 帮助
高级检索
当前位置： 首页 > 详情页

Elevated circulating CD19+CD24hiCD38hi B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：

收录情况： ◇ SCIE

作者：
Deng, Bishun[1] * ; Deng, Li[1] ; Liu, Miao[1] ; Zhao, Ziling[1] ; Huang, Huijie[1] ; Tu, Xiaoxin[1] ; Liang, Enyu[1] ; Tian, Ruimin[2,3] ; Wang, Xiaowan[2,3] ; Wang, Rongrong[2,3] ; Lin, Haibiao[1,2] ; Yu, Yongyi[4] ; Peng, Anping[1,2] ; Xu, Peng[2,3] ; Bao, Kun[2,3,*2] ; He, Min[1,2,*1] ;
机构： [1]Department of Laboratory Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China [2]State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [3]Department of Nephrology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [4]Department of Laboratory Medicine, Kaiping Central Hospital, JiangMen, China
出处：
DOI： 10.1016/j.imlet.2023.08.001
ISSN：

关键词： Regulatory B cells CD19+CD24 hi CD38 hi B cells Idiopathic membranous nephropathy Autoimmune disease T helper 17 cells

摘要：
CD19+CD24hiCD38hi regulatory B cells exert immunosuppressive functions by producing IL-10, but their role in idiopathic membranous nephropathy (IMN) remains elusive. Here, we investigated the frequency and functional changes of circulating CD19+CD24hiCD38hi B cells and evaluated the correlation of CD19+CD24hiCD38hi B cells with clinical features and T helper cell subsets in IMN patients. Compared with healthy controls (HCs), IMN patients showed an increased frequency of CD19+CD24hiCD38hi B cells, but a significant reduction in the percentage of CD19+CD24hiCD38hi B cells was observed 4 weeks after cyclophosphamide treatment. The frequency of CD19+CD24hiCD38hi B cells was positively correlated with the levels of 24h urinary protein, but negatively correlated with serum total protein and serum albumin, respectively. CD19+CD24hiCD38hi B cells in IMN patients displayed a skewed pro-inflammatory cytokine profile with a higher level of IL-6 and IL-12, but a lower concentration of IL-10 than their healthy counterparts. Accompanied by upregulation of Th2 and Th17 cells in IMN patients, the percentage of CD19+CD24hiCD38hi B cell subset was positively associated with Th17 cell frequency. In conclusion, CD19+CD24hiCD38hi B cells were expanded but functionally impaired in IMN patients. Their altered pro-inflammatory cytokine profile may contribute to the pathogenesis of IMN.

基金：
National Natural Science Foundation of China [81503317, 81974565]; State Key Laboratory of Dampness Syndrome of Chinese Medicine [SZ2021ZZ24, SZ2021ZZ09]; Science and Technology Planning Project of Guangzhou [202201020334, 202201020556, 202201020487]; Guangzhou Basic and Applied Basic Research project [202102021139]; Project of administration of Traditional Chinese Medicine of Guangdong Province of China [20221196]
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 3 区 医学
小类 | 4 区 免疫学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 免疫学
JCR分区：
出版当年[2021]版：
Q3 IMMUNOLOGY
最新[2023]版：
Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Laboratory Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China
通讯作者：
通讯机构： [1]Department of Laboratory Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, China [2]State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [3]Department of Nephrology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [*1]Department of Laboratory Medicine, the Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China. [*2]Department of Nephrology, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China.
推荐引用方式(GB/T 7714)：
Deng Bishun,Deng Li,Liu Miao,et al.Elevated circulating CD19+CD24hiCD38hi B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy[J].IMMUNOLOGY LETTERS.2023,261:58-65.doi:10.1016/j.imlet.2023.08.001.
APA：
Deng, Bishun,Deng, Li,Liu, Miao,Zhao, Ziling,Huang, Huijie...&He, Min.(2023).Elevated circulating CD19+CD24hiCD38hi B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy.IMMUNOLOGY LETTERS,261,
MLA：
Deng, Bishun,et al."Elevated circulating CD19+CD24hiCD38hi B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy".IMMUNOLOGY LETTERS 261.(2023):58-65

相关文献

[1]Astragalus membranaceus formula for moderate-high risk idiopathic membranous nephropathy: A meta-analysis [2]成人特发性膜性肾病的实验室诊断模型 [3]Herbal Medicine "Shulifenxiao" Formula for Nephrotic Syndrome of Refractory Idiopathic Membranous Nephropathy. [4]Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy. [5]Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis [6]Imbalance of T follicular helper cell subsets trigger the differentiation of pathogenic B cells in idiopathic membranous nephropathy [7]Real-World Effects of Chinese Herbal Medicine for Idiopathic Membranous Nephropathy (REACH-MN): Protocol of a Registry-Based Cohort Study. [8]特发性膜性肾病肾小管间质损伤与临床病理相关性研究 [9]Chinese medicinal herbs for idiopathic membranous nephropathy in adults with nephrotic syndrome A systematic review of effectiveness and safety [10]Real-World Effects of Chinese Herbal Medicine for Idiopathic Membranous Nephropathy (REACH-MN): Protocol of a Registry-Based Cohort Study.

资源点击量：2018 今日访问量：0 总访问量：645 更新日期：2024-07-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 广东省中医院 技术支持：重庆聚合科技有限公司 地址：广州市越秀区大德路111号