机构：[1]Department of Nephrology,First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China深圳市中医院深圳医学信息中心[2]Department of Echocardiography,First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China深圳市中医院深圳医学信息中心[3]Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China深圳市中医院深圳医学信息中心
To highlight current knowledge about M-type phospholipase A2 receptor (PLA2R) which is the first human autoantigen discovered in adult idiopathic membranous nephropathy.
Relevant articles published in English from 2000 to present were selected from PubMed. Searches were made using the terms "idiopathic membranous nephropathy, M-type PLA2R and podocyte."
Articles studying the role of M-type PLA2R in idiopathic membranous nephropathy were reviewed. Articles focusing on the discovery, detection and clinical observation of anti-PLA2R antibodies were selected.
M-type PLA2R is a member of the mannose receptor family of proteins, locating on normal human glomeruli as a transmembrane receptor. The anti-PLA2R in serum samples from MN were primarily IgG4 subclass. Technologies applied to detect anti-PLA2R autoantibody are mainly WB, IIFT, ELISA and so on. Studies from domestic and overseas have identified a strongly relationship between circulating anti-PLA2R levels and disease activity.
Recent discoveries corresponding to PLA2R facilitate a better understanding on IMN pathogenesis and may provide a new tool to its diagnosis, differential diagnosis, risk evaluation, response monitoring and patient-specific treatment.
基金：
This study was supported by a grant from the National Science
Foundation of China (No. 81373568).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区医学：内科
最新[2025]版：
大类|2 区医学
小类|2 区医学：内科
第一作者：
第一作者机构：[1]Department of Nephrology,First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
通讯作者：
通讯机构：[1]Department of Nephrology,First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China[*1]Department of Nephrology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
推荐引用方式(GB/T 7714)：
Wang Chao,Lu Huan,Yang Cui,et al.Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy.[J].Chinese Medical Journal.2014,127(10):1960-3.
APA：
Wang Chao,Lu Huan,Yang Cui&Luo Yuezhong.(2014).Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy..Chinese Medical Journal,127,(10)
MLA：
Wang Chao,et al."Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy.".Chinese Medical Journal 127..10(2014):1960-3
