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Engineering tumor-oxygenated nanomaterials: advancing photodynamic therapy for cancer treatment

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机构： [1]College of Biological Sciences and Technology, Yili Normal University, Yining, China. [2]Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. [3]No. 1 Traditional Chinese Medicine Hospital in Changde, Changde, China. [4]School of Public Health of Nantong University, Nantong, China. [5]Xinjiang Key Laboratory of Lavender Conservation and Utilization, Yining, China.

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关键词： nanomaterials photodynamic therapy reactive oxygen species hypoxia tumor oxygenation

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Photodynamic therapy (PDT), a promising treatment modality, employs photosensitizers to generate cytotoxic reactive oxygen species (ROS) within localized tumor regions. This technique involves administering a photosensitizer followed by light activation in the presence of oxygen (O2), resulting in cytotoxic ROS production. PDT's spatiotemporal selectivity, minimally invasive nature, and compatibility with other treatment modalities make it a compelling therapeutic approach. However, hypoxic tumor microenvironment (TME) poses a significant challenge to conventional PDT. To overcome this hurdle, various strategies have been devised, including in-situ O2 generation, targeted O2 delivery, tumor vasculature normalization, modulation of mitochondrial respiration, and photocatalytic O2 generation. This review aims to provide a comprehensive overview of recent developments in designing tumor-oxygenated nanomaterials to enhance PDT efficacy. Furthermore, we delineate ongoing challenges and propose strategies to improve PDT's clinical impact in cancer treatment.Copyright © 2024 Zuo, Li, Ma, Zhang, Li, Fan, Gao, Xia and Cheng.

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出版当年[2023]版：

大类 | 3 区工程技术

小类 | 3 区综合性期刊

最新[2025]版：

大类 | 3 区生物学

小类 | 3 区生物工程与应用微生物 4 区工程：生物医学

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第一作者机构： [1]College of Biological Sciences and Technology, Yili Normal University, Yining, China.

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通讯机构： [1]College of Biological Sciences and Technology, Yili Normal University, Yining, China. [5]Xinjiang Key Laboratory of Lavender Conservation and Utilization, Yining, China.

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