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Identification of haemoglobin New York by haemoglobin AIc measurement using the Sebia Capillarys 2 Flex Piercing system

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机构: [1]Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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关键词: Haemoglobin A(Ic) haemoglobin New York capillary electrophoresis ion-exchange high-performance liquid chromatography boronate affinity high-performance liquid chromatography immunoassay

摘要:
Haemoglobinopathies may interfere with the haemoglobin A(Ic) (HbA(Ic)) measurement, leading to incorrect diagnosis and inappropriate treatment. It is essential that HbA(Ic) assays are capable of identifying haemoglobinopathies. We report two cases of haemoglobin New York (HbNY) discovered through HbA(Ic) analysis using capillary electrophoresis (Capillarys 2 Flex Piercing [C2FP], Sebia). We used these samples to evaluate the ability of three other HbA(Ic) assays to identify this variant: ion-exchange high-performance liquid chromatography (Variant II Turbo [VII-T],Bio-Rad); boronate affinity high-performance liquid chromatography (Ultra 2, Trinity Biotech) and immunoassay (Cobas c501 Tina-quant Generation 3, Roche Diagnostics). Each method was used for HbA(Ic) assay of in samples from two cases of heterozygous haemoglobinopathy: beta(0)-thalassemia/HbNY (Case 1) and HbA/NY (Case 2). Only the C2FP system detected HbNY (an additional peak appeared between HbA(Ic) and HbA(0)). Clinical laboratories should be aware of the limitations of their HbA(Ic) assay methods especially in geographic areas, where haemoglobinopathy prevalence is high.

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基金编号: 2012BAI37B01 2012ZX09303009-003 81572088 2015A030313340 2014KT1593

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出版当年[2016]版:
大类 | 3 区 医学
小类 | 3 区 医学实验技术
最新[2025]版:
大类 | 4 区 医学
小类 | 4 区 医学实验技术
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出版当年[2015]版:
Q2 MEDICAL LABORATORY TECHNOLOGY
最新[2023]版:
Q3 MEDICAL LABORATORY TECHNOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

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第一作者机构: [1]Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
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通讯机构: [1]Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China [*1]Department of Laboratory Science, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 111 Dade Road, Guangzhou 510120, China.
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