机构：[a]Division of Nephrology, First Affiliated Hospital of Guangzhou, University of Traditional Chinese Medicine, 16 Jinching Road, Guangzhou, Guangdong, 510405, China[b]BGIShenzhen, Shenzhen, Guangdong, 518083, China[c]Shenzhen Engineering Laboratory for GenomicsAssisted Animal Breeding, BGIShenzhen, Shenzhen, Guangdong, 518083, China[d]Department of Internal Medicine, Guangdong Second ProvincialTraditional Chinese Medicine Hospital, Guangzhou, Guangdong, 510095, China[e]Division of Nephrology, First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510630, China
Tanshinone IIA (TIIA) is widely used for the treatment of a number human diseases, including diabetic nephropathy (DN) (1). The present study was performed to examine the role of the transforming growth factor β (TGFβ)/p65 pathway under TIIA treatment in a glomerular mesangial cell model of DN. Firstly, it was identified that TIIA inhibited the proliferation of HBZY1 cells, while simultaneously suppressing the expression of TGFβ and p65. In addition, glucose-induced HBZY1 cells were treated with TIIA, siTGFβ and sip65. The results revealed that siTGFβ or sip65 were able to inhibit the proliferation of HBZY1 cells as well. Finally, the expression of TGFβ and p65 in a rat model of DN treated with TIIA was detected. The results demonstrated that renal hypertrophy and 24 h urinary protein excretion were ameliorated in TIIA-treated rats with DN. Furthermore, it was revealed that the protein levels of TGFβ and p65 were decreased in the DN rats following TIIA treatment. In conclusion, the present study demonstrated that TGFβ and p65 were activated by TIIA in HBZY1 cells. In addition, the expression of TGFβ and of p65 was downregulated in rats with DN treated with TIIA.
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外文
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区肿瘤学
第一作者：
第一作者机构：[a]Division of Nephrology, First Affiliated Hospital of Guangzhou, University of Traditional Chinese Medicine, 16 Jinching Road, Guangzhou, Guangdong, 510405, China
通讯作者：
通讯机构：[a]Division of Nephrology, First Affiliated Hospital of Guangzhou, University of Traditional Chinese Medicine, 16 Jinching Road, Guangzhou, Guangdong, 510405, China[*1]Division of Nephrology, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, 16 Jinching Road, Guangzhou, Guangdong 510405, P.R. China
推荐引用方式(GB/T 7714)：
Chen G,Zhang X,Li C,et al.Role of the TGFβ/p65 pathway in tanshinone IIA-treated HBZY1 cells(Open Access)[J].Molecular medicine reports.2014,10(5):2471-6.doi:10.3892/mmr.2014.2497.
APA：
Chen, G,Zhang, X,Li, C,Lin, Y,Meng, Y&Tang, S.(2014).Role of the TGFβ/p65 pathway in tanshinone IIA-treated HBZY1 cells(Open Access).Molecular medicine reports,10,(5)
MLA：
Chen, G,et al."Role of the TGFβ/p65 pathway in tanshinone IIA-treated HBZY1 cells(Open Access)".Molecular medicine reports 10..5(2014):2471-6
