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Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.

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资源类型：
Pubmed体系：

收录情况： ◇ EI

作者：
Shijie Li[a] * ; Zhuoyue Song[a] * ; Tingting Liu[c] * ; Jian Liang[a] ; Jun Yuan[b] ; Zhanchi Xu[a] ; Zhanghua Sun[a] ; Xiaoping Lai[a] ; Qingping Xiong[a] ; Danyan Zhang[a] ;
机构： [a]Mathematical Engineering Academy of Chinese Medicine, and School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China [b]Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huaiyin Institute of Technology, Huai′an 223003, Jiangsu, PR China [c]Affiliated Huai'an Hospital of Xuzhou Medical University, Huai′an 223001, Jiangsu, PR China
出处：
DOI： 10.1016/j.carbpol.2018.01.075
ISSN：

关键词： Polysaccharide Ostrea rivularis Reproductive oxidative stress damage Keap1-Nrf2/ARE pathway

摘要：
The purpose of this study was to investigate the effects of Ostrea rivularis polysaccharide (ORP) against testicular oxidative stress injury via kelch-like ECH-associated protein 1-nuclear erythroid 2-related factor 2/antioxidant response element (Keap1-Nrf2/ARE) pathway. In pharmacological experiments in vivo, ORP administration could dose-dependently inhibit body and testicular weight loss, ameliorate epididymal sperm quality and protect reproductive impairment in cyclophosphamide-induced male Balb/c mice. Moreover, the mechanism in vivo might be elucidated that ORP could increase expression level of Nrf2 and its downstream ARE gene battery in the testis, promote production of corresponding antioxidative enzymes and protein, and enhance Keap1-Nrf2/ARE signaling pathway to avoid male reproductive dysfunction. In addition, ORP treatment could improve survival capacity of H2O2-induced TM4 cells and its antioxidant mechanism in vitro also had been verified to activate Keap1-Nrf2/ARE signaling pathway. Overall, these results showed that ORP as a potent antioxidant could reduce reproductive oxidative stress damage related to Keap1-Nrf2/ARE pathway. Copyright © 2018 Elsevier Ltd. All rights reserved.

基金：
This work was partly supported by the National Natural Science Foundation of China (No. 81503387), Natural Science Fund for Colleges and Universities in Jiangsu Province of China (No. 15KJB360002), Six Talent Peaks Project in Jiangsu Province (2015-XCL-036, 2017-YY-003), Qing Lan Project of Jiangsu Province, Guangdong Provincial Science and Technology Program − Basic Conditions for Construction of Science and Technology Projects (No. 2014A030304059), Application Science and Technology Research Special Program of Guangdong (No. 2015B020234008) and Open Funds of Jiangsu Key Laboratory of Special Resource Development and Medical Research (LPRK201704), the construction of high level university in Guangzhou University of Chinese Medicine (A1-AFD018161Z1521).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 2 区 化学
小类 | 1 区 应用化学 2 区 有机化学 2 区 高分子科学
最新[2025]版：
大类 | 1 区 化学
小类 | 1 区 应用化学 1 区 有机化学 1 区 高分子科学
第一作者：
第一作者机构： [a]Mathematical Engineering Academy of Chinese Medicine, and School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, Guangdong, PR China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Shijie Li,Zhuoyue Song,Tingting Liu,et al.Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.[J].Carbohydrate polymers.2018,186:321-331.doi:10.1016/j.carbpol.2018.01.075.
APA：
Shijie Li,Zhuoyue Song,Tingting Liu,Jian Liang,Jun Yuan...&Danyan Zhang.(2018).Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway..Carbohydrate polymers,186,
MLA：
Shijie Li,et al."Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.".Carbohydrate polymers 186.(2018):321-331

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