机构：[1]Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2]Guangzhou Univ Tradit Chinese Med, Postdoctoral Res Stn, Guangzhou 510006, Guangdong, Peoples R China
This study showed that abnormal behavioral changes were greatly improved in rats displaying Parkinson's disease-like symptoms after intragastric administration of Xifeng Dingchan decoction at 15, 7.5, 3.75 g/kg per day. In addition, tyrosine hydroxylase mRNA expression in the substantia nigra of the midbrain was up-regulated, and tyrosine hydroxylase content in the midbrain ventral tegmentum and substantia nigra pars compacta was also increased. The effect of administration of Xifeng Dingchan decoction at 7.5 g/kg per day was similar to that of Madopar at 67.5 mg/kg per day. These results indicate that the therapeutic effect of Xifeng Dingchan decoction on Parkinson's disease is associated with the up-regulated protein and mRNA expression of tyrosine hydroxylase in the midbrain.
基金：
Heilongjiang Province Administration of Traditional Chinese Medicine [ZH04Z74]
第一作者机构：[1]Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2]Guangzhou Univ Tradit Chinese Med, Postdoctoral Res Stn, Guangzhou 510006, Guangdong, Peoples R China
通讯作者：
通讯机构：[1]Guangzhou Univ Tradit Chinese Med, Dept Neurol 1, Clin Med Coll 2, Guangzhou 510120, Guangdong, Peoples R China[2]Guangzhou Univ Tradit Chinese Med, Postdoctoral Res Stn, Guangzhou 510006, Guangdong, Peoples R China
推荐引用方式(GB/T 7714)：
Luo Enli.Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction[J].NEURAL REGENERATION RESEARCH.2011,6(12):914-918.doi:10.3969/j.issn.1673-5374.2011.12.006.
APA：
Luo, Enli.(2011).Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction.NEURAL REGENERATION RESEARCH,6,(12)
MLA：
Luo, Enli."Tyrosine hydroxylase expression in the midbrain of Parkinson's disease model rats treated with Xifeng Dingchan decoction".NEURAL REGENERATION RESEARCH 6..12(2011):914-918
