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LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond.

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机构： [1]Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. [2]The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, Guangdong, China. [3]State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, Jiangsu, China. [4]Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China. [5]Jiangsu Kanion Pharmaceutical CO. LTD, Lianyungang 222001, Jiangsu, China. [6]Center for Biosystems Dynamics Research, RIKEN, 2‑2‑3 Minatojima‑minamimachi, Chuo‑ku, Kobe, Hyogo 650‑0047, Japan.

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关键词： lncRNA DNA methylation Non-coding RNA DNMT TET Cancer

摘要：

DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-specific DNA methylation patterns established or disturbed is a pivotal question in developmental biology and cancer epigenetics. Currently, compelling evidence has emerged that long non-coding RNA (lncRNA) mediates DNA methylation in both physiological and pathological conditions. In this review, we provide an overview of the current understanding of lncRNA-mediated DNA methylation, with emphasis on the roles of this mechanism in cancer, which to the best of our knowledge, has not been systematically summarized. In addition, we also discuss the potential clinical applications of this mechanism in RNA-targeting drug development.© 2022. The Author(s).

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出版当年[2021]版：

大类 | 1 区

医学

小类 | 1 区肿瘤学

最新[2025]版：

大类 | 1 区

医学

小类 | 1 区肿瘤学

第一作者：

第一作者机构： [1]Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. [2]The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, Guangdong, China. [3]State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, Jiangsu, China.

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通讯机构： [1]Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China. [2]The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, Guangdong, China. [3]State Key Laboratory of New-Tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, Jiangsu, China. [5]Jiangsu Kanion Pharmaceutical CO. LTD, Lianyungang 222001, Jiangsu, China.

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