详情页 - 广东省中医院知识库

当前位置：首页 > 详情页

Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke.

11| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States [2]International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden [3]Department of Clinical Neurosciences, University of Medicine & Pharmacy, Cluj-Napoca, Romania [4]“RoNeuro” Institute for Neurological Research and Diagnostic, Cluj-Napoca, Romania [5]Department of Neurosurgery, Chinese Medicine Hospital of Guangdong Province, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Yuexiu, Guangzhou, China [6]Department of Clinical Pharmacology and Toxicology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania [7]LaNCE, Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Bizkaia, Spain [8]Department of Pathology, University of Maryland, Baltimore, MD, United States [9]Anesthesiology & Intensive Care, Massachusetts General Hospital, Boston, MA, United States [10]Department of Biomaterials, School of Biomedical Engineering, Indian Institute of Technology, Banaras Hindu University, Varanasi, India [11]Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden

出处：

DOI：

ISSN：

关键词： Heat stroke Brain edema Hyperthermia Gingko Biloba EGb-761 Nanowired delivery Neuroprotection Blood-brain barrier Brain pathology

摘要：

Military personnel often exposed to high summer heat are vulnerable to heat stroke (HS) resulting in abnormal brain function and mental anomalies. There are reasons to believe that leakage of the blood-brain barrier (BBB) due to hyperthermia and development of brain edema could result in brain pathology. Thus, exploration of suitable therapeutic strategies is needed to induce neuroprotection in HS. Extracts of Gingko Biloba (EGb-761) is traditionally used in a variety of mental disorders in Chinese traditional medicine since ages. In this chapter, effects of TiO2 nanowired EGb-761 and BN-52021 delivery to treat brain pathologies in HS is discussed based on our own investigations. We observed that TiO2 nanowired delivery of EGb-761 or TiO2 BN-52021 is able to attenuate more that 80% reduction in the brain pathology in HS as compared to conventional drug delivery. The functional outcome after HS is also significantly improved by nanowired delivery of EGb-761 and BN-52021. These observations are the first to suggest that nanowired delivery of EGb-761 and BN-52021 has superior therapeutic effects in HS not reported earlier. The clinical significance in relation to the military medicine is discussed.Copyright © 2021 Elsevier B.V. All rights reserved.

基金：

语种：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版中科院分区表Review为是的期刊

：

大类 | 3 区医学

小类 | 4 区神经科学

最新[2025]版：

无

JCR分区：

出版当年[2019]版：

Q4 NEUROSCIENCES

最新[2023]版：

无

影响因子： 0 最新[2023版] 0 最新五年平均 1.746 出版当年[2019版] 3.061 出版当年五年平均 2.961 出版前一年[2018版] 2.453 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Chemistry & Biochemistry, University of Arkansas, Fayetteville, AR, United States

通讯作者：

推荐引用方式(GB/T 7714)：

APA：

MLA：

Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke.

文献详情

相关文献