机构：[1]National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China[2]Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China[3]Ganzhou People’s Hospital, Ganzhou, China[4]College of TCM, Guangdong Pharmaceutical University, Guangzhou, China
Three new flavonoid glycosides, Dasuanxinoside F-H (1-3), were isolated from the aerial parts of Allium sativum, together with eight known compounds which were firstly reported in this plant, including three flavonoid glycosides (4-6) and five phenylethanoid glycosides (7-11). Their structures were identified by UV-vis, IR, 1D and 2D NMR spectra, as well as HR-ESI-MS analyses. The inhibitory effect of the isolated compounds on platelet aggregation induced by adenosine diphosphate (ADP) was evaluated in vitro. The results showed that most compounds displayed different degrees of inhibition. Among them, 2, 5, 8 and 9 exhibited the strongest activity on platelet aggregation.
基金：
This work was supported by the [Chinese Medicine Science and Technology Plan Project of
Jiangxi Province] under Grant [number 2020A0357]; [Starting Fund for Scientific Research of
High-level Talents of Gannan Medical University] under Grant [number QD202009]; and [Key
special project of “Research on modernization of traditional Chinese medicine” in national key R
& D plan of China] under Grant [number 2018YFC1707100].
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区化学
小类|3 区应用化学3 区药物化学
最新[2025]版：
大类|3 区化学
小类|3 区应用化学4 区药物化学
第一作者：
第一作者机构：[1]National Engineering Research Center for Modernization of Traditional Chinese Medicine-Hakka Medical Resources Branch, School of Pharmacy, Gannan Medical University, Ganzhou, China[2]Key Laboratory of Chinese Materia Medica, School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
通讯作者：
推荐引用方式(GB/T 7714)：
Hu Bin,Hu Haibo,Pu Chuan,et al.Three new flavonoid glycosides from the aerial parts of Allium sativum L. and their anti-platelet aggregation assessment.[J].Natural product research.2022,1-10.doi:10.1080/14786419.2022.2047045.
APA：
Hu Bin,Hu Haibo,Pu Chuan,Wei Zheng,Wang Qiuhong&Kuang Haixue.(2022).Three new flavonoid glycosides from the aerial parts of Allium sativum L. and their anti-platelet aggregation assessment..Natural product research,,
MLA：
Hu Bin,et al."Three new flavonoid glycosides from the aerial parts of Allium sativum L. and their anti-platelet aggregation assessment.".Natural product research .(2022):1-10
