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Two heteropolysaccharides from Isaria cicadae Miquel differ in composition and potentially immunomodulatory activity.

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机构： [a]Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510006, PR China [b]Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an 223002, Jiangsu, PR China

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关键词： Isaria cicadae Miquel Polysaccharide Immunomodulatory activity

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Two novel heteropolysaccharides (JCH-1 and JCH-2) with molecular weights of 30.9 and 555.3 kDa were first extracted, isolated and purified from Isaria cicadae Miquel (I. Miquel). Monosaccharide analysis showed that JCH-1 and JCH-2 were composed of mannose, glucose and galactose with different monosaccharide ratio. In addition, JCH-1 had higher contents of sulfated and uronic acid compared to JCH-2. Based on MTT assay, JCH-1 and JCH-2 could markedly promote the proliferation of RAW264.7 cells and exhibit no cytotoxicity at a specific concentration range. The immunomodulatory assay exhibited that JCH-1 and JCH-2 could significantly enhance the viability of macrophage cells, and promote the release of NO, IL-6 and TNF-α. Furthermore, the immunomodulatory activity of JCH-1 was significantly better than that of JCH-2. These results proposed that I. Miquel had two polysaccharide fractions with different composition and JCH-1 is better to be developed as a functional food with the better immunomodulator activity. Copyright © 2018 Elsevier B.V. All rights reserved.

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出版当年[2017]版：

大类 | 3 区生物

小类 | 2 区应用化学 2 区高分子科学 3 区生化与分子生物学

最新[2025]版：

大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

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第一作者机构： [a]Guangzhou University of Chinese Medicine, Guangdong, Guangzhou 510006, PR China

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